The EU-funded MSCA-ITN ‘MgSafe’ investigates a novel combination of imaging technologies for biodegradable magnesium implants in order to promote patient safety.
The PhD candidates will quantify the physical impact and suitability of a variety of modalities on Mg implants. Highly sophisticated imaging techniques (nano and μCT, MRT, PET, USPA, IR) will be developed beyond the forefront of medical device production. This will be done in vivo and with in situ labelling options to deliver non-invasively data on different time and length scales. The body reaction and material behaviour will be investigated during Mg degradation with a precision and plethora of details, which is currently not available.
We are looking for highly motivated candidates for the following PhD projects:
The research topic is to establish and combine imaging techniques to evaluate magnesium-based implants in juvenile and adult rats. The applicant will surgically implant the material into rat femura. Additionally, he/she will (i) quantify implant degradation and bone response in vivo together with molecular activities of osteoblast, osteoclast and inflammatory cells; (ii) histologically correlate with fluorescence signal of osteoblast, osteoclast and inflammatory response; (iii) determine the metabolical phenotype of bone and surrounding tissue by ex vivo NMR; (iv) deliver data, explants and tissue to network partners.
The applicant holds a master’s degree in biochemistry, biology, or related life science areas. He/she is able to apply standard methods and willingness to learn novel techniques is of utmost importance and is experienced in state-of-the-art techniques. Expertise in animal handling, biomaterials or orthopaedics is advantageous.
Medical University of Graz, Department of Orthopedics and Traumatology, Graz, Austria (Prof. Annelie-Martina Weinberg)
The research topic is the quantitative and qualitative evaluation of Mg-based implants in growing sheep. The applicant will surgically implant the material into the tibiae of juvenile sheep. Additionally, he/she will (i) quantitatively and qualitatively analyse the implantation site with regard to clinically relevant aspects; (ii) determine the suitable, clinically relevant implant shape and Mg amount with respect to possible local side effects (osteolysis, necrosis, pseudoarthrosis); (iii) analyse the degradation behaviour (volume and surface changes) and gas evolution in sheep; (iv) evaluate the related biomechanical properties of the Mg-based implants with regard to yield strength, elastic modulus, ultimate tensile strength for the specific application and comparison to a standard implant.
The applicant holds a master’s degree in (biomedical) engineering, or related life science areas, such as medicine. The ability to apply standard methods and willingness to learn novel techniques is of utmost importance. Experience in state-of-the-art techniques is required. Expertise in animal handling, imaging techniques, such as clinical CT or microCT, in the mechanics of up-to-date biomedical materials or orthopaedics is advantageous.
Medical University of Graz, Department of Orthopedics and Traumatology, Austria (Prof. Annelie-Martina Weinberg) in cooperation with Graz University of Technology, Institute of Biomechanics, Graz, Austria (Prof. Gerhard A. Holzapfel)
The research topic is to evaluate the biological performance of implants made of magnesium alloys in vivo and in vitro. The applicant has to verify correlation between imaging techniques (microCT, PET, MRI) with immunohistology and histological evidence in vivo. This will involve techniques like embedding of hard tissue, histomorphometry and immunohistochemistry. He/she is able to apply standard methods to characterise cell type, evaluate cell and tissue morphology, and tissue regeneration.
The applicant holds a master’s degree in medicine, biochemistry, biology, or related areas. Experience in cell culture work and/or histology/immunohistology (ideally in the area of bone and bone remodelling) is desirable. Expertise in imaging (e.g. microscopy, microCT) is requested.
Department of Biomaterials, Institute for Clinical Dentistry, University of Oslo, Norway (Prof. Dr. H.J. Haugen)
The research topic focuses on the biological reactions to biodegradable Mg-based implants and aims at evaluation of the cellular and molecular events during healing and implant degradation. Furthermore, the structural evolution during healing will be studied using a range of microscopy and spectroscopy techniques in order to gain an increased understanding of how degradable materials influence the structural parameters of bone as compared to healing around permanent materials such as titanium. The knowledge generated in this project is of fundamental importance for the translation to safe clinical use.
The specific research questions addressed during the project are:
The project involves state-of-the-art, cellular and molecular techniques and a broad range of microscopy techniques to evaluate the different hierarchical levels of
osseointegration, from molecular events and nanoscale interactions to macroscale function. Further, the project includes experimental in vivo models.
The applicant holds a master’s degree in materials science, dentistry, medicine, or related areas.
Department of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (Prof. P. Thomsen)
The research topic is the longitudinal 3D physiological measurements in rats by MRT/MRS, multimodal approaches MRT/USPA and FMT/μCT. Development and optimisation of imaging procedures. Imaging of Mg implant degradation and monitoring the functional changes of tissue parameters (inflammation/angiogenesis/oxygenation). The applicant will be involved in surgical procedures on animals, will produce and analyse complex data with respect to the property profile of materials.
The applicant holds a master’s degree in veterinary or biomedical science, or related areas. He/she is willing to be involved in animal research. Experience in at least one of the areas of imaging technologies, small animal surgery, laboratory animal science, processing and analysis of matrix data (ideally in the area of magnetic resonance spectroscopy) is required. Expertise in animal handling, basic statistics, basics of imaging physics and imaging technologies is requested.
Hannover Medical School, Institute for Laboratory Animal Science, Combinatorial Imaging Facility, CiF, Hannover, Germany (Dr. M. Meier)
The research topic is multimodal imaging of bone regeneration and bone remodelling after implantation of a degradable Mg-based device in experimental animal models. The specific objectives will be: (1) Study of the dynamic regulation of bone regeneration and remodelling. (2) Validation of the probes/target combination, both in vitro and in vivo, following a multimodal approach by small animal Positron Emission Tomography (PET), High frequency Ultrasound (HF-US), and photoacoustic imaging (PAI). (3) Integration of bone metabolism and homeostasis by morphometric measurements. (4) Development of new preclinical imaging strategies for translation in a clinical setting.
The applicant holds a master’s degree in chemistry, pharmaceutical chemistry, pharmacy, or physics and is interested in multi/ interdisciplinary research. Experience with tracer chemistry and physics is required.
National Research Council (CNR) Institute of Clinical Physiology, Pisa, Italy (Prof. L. Menichetti)
The research topic is to assess circulating biomarkers in order to predict and/or monitor efficacy/toxicity of the degradable implant through a multi-marker technology. This will lead to the development of an integrated approach for biomarker development in the field of Mg-implants. This approach shall be integrated with multimodal and molecular imaging of bone regeneration and remodelling after implantation of degradable Mg-based devices. The specific goals will be: (1) in vitro validation studies with specific probes labelling integrin αvβ3 to detect angiogenesis in vivo; (2) validation of the probes/target combination with state-of-art technologies, both in vitro and in vivo, following a multimodal approach by small animal Positron Emission Tomography (PET), high resolution ultrasound (HR-US) and photoacoustic imaging (PAI), (3) integration of biohumoral and biochemical information with image-derived parameters of bone metabolism.
The applicant holds a master’s degree in biological chemistry, biology, pharmaceutical chemistry, pharmacy, or medicine and is interested in multi/ interdisciplinary research. Experiences in the fields of (bone) tissue remodelling and inflammation biomarkers are advantageous.
National Research Council (CNR) Institute of Clinical Physiology, Pisa, Italy (Prof. L. Menichetti)
The research topic is focusing on the development and optimisation of an optical near infrared probe for the measurement and analysis of absorption spectra and local perfusion at the implant-tissue interface. The applicant will develop an optical probe for measurements of physiological parameters such as oxygenation, pH and related physiological parameters to compare with morphological changes at the implant’s interface. Standard methods for optical measurement techniques and fibre optical probes will be applied for the design of the probe. In addition, multivariate calibration and Statistical Parameter Mapping (SPM) methods are the main tools in this project.
The applicant holds a master’s degree in electronics, biomedical engineering, or relevant fields with 120ECTS or equivalent level that is approved by NOKUT (the Norwegian Agency for Quality Assurance in Education). The candidate has average grades of A (best grade) or B within a scale of A-E passing grades in his/her master degree. Furthermore, expertise in the optical instrumentation, calibration and analysis of optical spectroscopy methods, validation of measurements is desired. Experience in near infrared spectroscopy, optical characterisation in tissue and analysis of optical data is requested. Experience in developing optical and medical instruments and sensors, and programming skills (e.g. Matlab) will be beneficial.
Oslo Metropolitan University, Faculty of Technology, Art and Design, Department of Mechanical, Electrical and Chemical Engineering, Oslo, Norway (Dr. Mirtaheri)
The research topic is the characterisation of the corrosion layer structure and composition in explants. The applicant will characterise surface and interface properties as well as the topography of Mg-explants after in vivo degradation. He/she will operate equipment like SEM, TEM, EDX and AFM including sample preparation. Additional knowledge in the area of biomaterials is required.
The applicant holds a master’s degree in materials science, chemistry, or related area with specific focus on biomaterials. Experience in materials surface characterisation of light metals and their interaction with biological cells or tissues is required. Basic expertise in operation of Scanning Electron Microscopy and Atomic Force Microscopy is mandatory. The applicant will work with explants and is familiar with the preparation of biological samples.
Biomaterials Group, Materials Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland
Supervisor: Prof. W. Swieszkowski
The research topic is imaging and characterisation of Mg implants in native tissue environments. This will be investigated by applying high‐energy differential phase contrast (DPC) tomographic imaging, and create multimodal image data sets integrating phase, attenuation and dark field CT‐data. The project will focus on the optimisation of SR tomography contrast techniques and data analysis protocols for the characterisation of metallic implant tissue interfaces and the implementation of
approaches for multimodal data analysis e.g. including Deep / Machine Learning approaches.
The applicant holds a master’s or diploma degree in physics, or related areas. Experience in the field of x-ray imaging and image processing, including processing/scripting skills to develop custom data analysis pipelines, is required. Expertise in instrumentation and setup development is highly appreciated.
HZG-outstation at DESY, Hamburg, of the Helmholtz-Zentrum Geesthacht, Institute for Materials Research, Germany (Prof. R. Willumeit-Römer)
The aim of the research topic is the investigation of the bone implant interface by use of high‐resolution x-ray scattering. The applicant will perform diffraction and small angle x‐ray scattering experiments with x-ray beams of the size of 250 nm to elucidate differences in bone structure close to the implant interface and in distant bone and to investigate if corrosion products (e.g. hydroxyapatite) are ordered in a bone like fashion. This is complemented by histological and spectroscopic techniques to correlate structure and function of degradable implants.
The applicant holds a master’s degree in physics, mathematics, or related areas. Experience in x-ray scattering, ideally x-ray diffraction or small angle scattering, and/or programming is required. Knowledge in the field of machine learning would be beneficial.
HZG- outstation at DESY, Hamburg, of the Helmholtz-Zentrum Geesthacht, Institute for Materials Research, Germany (Prof. R. Willumeit-Römer)
The research topic is the software development for management and visualisation of multimodal data, development of visualisation methods depicting the evolution of magnesium implants using volume-rendering algorithms of any pre-registered multimodal volumes. It also implies the comparison with low-resolution 3D data for the understanding of the processes involved and the development of new contrast imaging techniques for human applications.
The applicant holds a master’s degree in computer science or mathematics, materials science, or related areas. Experience in algorithm developments & image processing - ideally in a biomedical field – is required.
SCANCO Medical AG, Bruettisellen, Switzerland (Dr. V. Stadelmann)
The research topic is the development and optimisation of Magnetic Resonance Imaging (MRI) techniques for degradable implant applications. A Mg-based conductive implant in the patient’s body interacts with the radiofrequency (RF) field of an MR scanner. This may result in local RF induced heating in the tissue, which might constitute a patient safety hazard. For going en route to clinical applications of Mg implants, it is essential to understand and control the interaction of passive, conducting Mg-based implants with RF fields. Here, our research will focus on (1) electromagnetic field (EMF) simulations to detail electric fields and local RF power deposition in humans for frequencies accommodating today’s clinical and research MR scanners, (2) E-field measurements to benchmark the outcome of the computational modelling with experiments, (3) thermal numerical simulations and its verification in RF heating experiments, (4) development of an implant friendly radiofrequency antenna using multi-channel transmission MR, (5) development of RF shimming algorithms that use the degrees of freedom of multi-channel transmission to generate reduced RF field zones or “null mode” excitations that induce minimal RF current in Mg implants, thereby decreasing the RF heating hazard, while still allowing imaging of the surrounding volume.
The position would be well suited for applicants with an open minded interest in medical imaging, expertise in numerical simulations or with a strong hardware background, with strong initiative and excellent communication skills. The candidate holds a master’s degree (Master of Science or equivalent) in physics, electrical engineering, biomedical engineering, computer science, or a related discipline. Hardware development and/or signal/image processing experience is beneficial.
MRI.TOOLS GmbH, Robert-Roessle Strasse 10, 13125 Berlin, Germany (Prof. T. Niendorf) Interested candidates should please contact niendorf(at)mritools(dot)de for more details.
The research topic is the determination of the impact of radiofrequency on heating of Mg-implants. The applicant will develop test plans to study the influence of implant degradation on the MR signal, including the determination of the implant’s state of degradation. For this purpose, implants in different in vivo and in vitro degradation states will be scanned with different parameter sets. Besides minimising heating, dislocation and antennae effects that potentially occur during MR-scanning, an
optimised visualisation of the degradation zone shall be achieved. Following this, the translation of the animal studies’ results into human applications will be tackled.
The applicant holds a master’s degree or diploma in materials science, (imaging) physics, or related areas. Expertise in the field of material characterisation by x-ray imaging and MR-imaging is required. Knowledge of MR parameters and the interaction of MR signals with (light) metals is advantageous. The applicant should be able to design and support in vitro and in vivo studies.
Syntellix AG and MHH, Research and Development, Hannover, Germany (F. Zaage, Dr. J.-M. Seitz)
The research topic is to work on the design of the photoacoustic imaging system. The current approach will be optimised for small animal imaging (mice/rat). The applicant will modify the transducer and the working interface to meet the needs of patient monitoring. This non-invasive imaging approach is ideal for the long-term follow up of implant degradation. The results will be validated with other imaging approaches.
The applicant holds a master’s degree in physics, biomedical engineering, biology, or related areas. He/she has expertise in preclinical or clinical imaging (e.g. ultrasound, photoacoustics, MRI, CT or similar). Ideally, the candidate holds a FELASA certificate.
Fujifilm Visualsonics, Amsterdam, the Netherlands (Dr. J. Jose)
Applicants need to be Early-Stage Researchers. They must, at the date of recruitment, be in the first four years (full-time equivalent research experience) of their research careers (= after acquiring MSc degree or similar) and have not been awarded a doctoral degree yet.
Researchers can be of any nationality. They are required to undertake physical, transnational mobility (i.e. move from one country to another) when taking up their appointment. Mobility rule: researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of the recruiting beneficiary for more than 12 months in the 3 years immediately before the recruitment date.
Starting from April 1st 2019, the positions will be awarded for three years.
Please send your application in English indicating job offer code no. 2018/WB 5 and which position you are interested in by email preferably in one pdf file not exceeding 10 MB to application.mgsafe(at)hzg(dot)de. Please DO NOT send applications via email to individual PIs or organisations. Such emails will not be considered.
Make sure that your application includes: